Our laboratory uses a structural (CryoEM, X-ray crystallography, NMR) and molecular biology approach combined with biophysical assays to investigate the molecular aspects of attachment proteins of emerging pathogens and interactions with the host and other microbes.
Proteins are often seen as rigid bodies, however, they experience a multitude of molecular motions occurring on various timescale. Can alteration of protein motions be a mechanism to promote immune evasion?
If proteins (and protein-protein interactions) allow for conformational flexibility (or motions), can we exploit this property toward engineering better therapeutics?
Viral and fungal pathogens use a broad diversity of host-cell receptors to promote entry and invasion. We will define the structural, molecular and biophysical aspects of the host-pathogen interactome.
Offline Website Software